HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 641735Generated: October 30, 2026
Phosphorus oxychloride → 7-Quinazolinol, 4-chloro-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, 7-acetate
https://huagongshe.com/reaction/641735
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 7-(Acetyloxy)-5-[(tetrahydro-2H-pyran-4-yl)oxy]-4(3H)-quinazolinone | HCID 135510677 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 7-Quinazolinol, 4-chloro-5-[(tetrahydro-2H-pyran-4-yl)oxy]-, 7-acetate | HCID 22140798 | — |
Reaction Steps
A mixture of 7-acetoxy-5-tetrahydropyran-4-yloxy-3,4-dihydroquinazolin-4-one (3.04 g), diisopropylethylamine (4.34 ml), phosphoryl chloride (1.02 ml) and 1,2-dichloroethane (60 ml) was stirred and heated to 80° C. for 2 hours. The mixture was evaporated to give 7-acetoxy-4-chloro-5-tetrahydropyran-4-yloxyquinazoline which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07696214B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-e0e98ad953b3488dbae7ae325bc887be |
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| Source note | uspto-grants-2010_04 |
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