Carbon Tetrachloride → 5-(1-Tert-butoxycarbonylpiperidin-4-yloxy)-4-chloroquinazoline

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Reaction Steps

5-(1-tert-butoxycarbonylpiperidin-4-yloxy)-3,4-dihydroquinazolin-4-one (0.31 g) was reacted with triphenylphosphine and carbon tetrachloride to give 5-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-chloroquinazoline (0.156 g); NMR Spectrum: (CDCl3) 1.5 (s, 9H), 1.9-2.1 (m, 4H), 3.5-3.8 (m, 4H), 4.8 (m, 1H), 7.05 (d, 1H), 7.65 (d, 1H), 7.82 (m, 1H), 8.95 (s, 1H); Mass Spectrum: M+H+ 364 and 366; and

Provenance & Evidence