反应详情

温度

85 °C

To a solution of N-(5-(5-cyano-1H-benzo[d]imidazol-1-yl)-2′,4′-difluoro-[1,1′-biphenyl]-3-yl)acetamide (0.5 g, 1.28 mmol, 1 eq.) in ethanol (10 ml) was added 20% aqueous solution of potassium hydroxide (0.721 g, 12.88 mmol, 10 eq.) and the mixture was heated at 85° C. for 5 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford title product in 71% yield (0.32 g). LC-MS (ESI): Calculated mass: 364.11; Observed mass: 365.1 [M+H]+ (rt: 0.59 min).

1. customThe mixture was quenched
2. extractionextracted as in Example 1(d)
3. distillationThe solvent was distilled off