4-Chloroaniline → HCID 10452511, compound

HRID 641793Notes

Reaction equation

HRID 641793 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]([C:11]2[S:12][CH:13]=[CH:14][C:15]=2[NH2:16])=[O:10])=[CH:4][CH:3]=1.ClC1C=CC(N)=CC=1.[NH:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][N:32]=2)[C:27]([CH:34]=O)=[CH:26]1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[S:12][CH:13]=[CH:14][C:15]=2[NH:16][CH2:34][C:27]2[C:28]3[C:33](=[N:32][CH:31]=[CH:30][CH:29]=3)[NH:25][CH:26]=2)=[O:10])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 78124-ChloroanilineHCID 53728121H-Pyrrolo[2,3-b]pyridine-3-carbaldehydeHCID 61092440HCID 61092440, compound

Product 1

HCID 10452511HCID 10452511, compound

Procedure

Prepared according to the procedure described in EXAMPLE 5 using N-(4-chlorophenyl)3-aminothiophene-2-carboxamide (prepared as described in EXAMPLE 1, part 1, using 4-chloroaniline instead of 4-trifluoromethoxyaniline) and 7-azaindole-3-carboxaldehyde (EXAMPLE 8, part 1) instead of 2-(N-methylcarbamoyl)pyridine-4-carboxaldehyde. MS (ES+): 383, 385 [MH+]

Workup

  1. customPrepared
  2. customprepared

Sources & evidence

ORD record
ord-0eb2d424ca174787a865e937173b7171
Source dataset
uspto-grants-2010_04
Patent number
US07696225B2

Reaction notes

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