Sodium Carbonate → N,N-Dimethyl-6-((E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)vinyl)naphthalen-2-amine

참여 물질

반응 조건

반응 단계

Dry DMF (10 mL) was added by syringe to the mixture of 6-bromo-N,N-dimethylnaphthalen-2-amine (200 mg, 0.8 mmol), 2,5-dimethyl-1-phenyl-3-vinyl-1H-pyrrole (236 mg, 1.2 mmol), Na2CO3 (254 mg, 2.4 mmol), n-Bu4NCl (224 mg, 0.8 mmol) and Pd(OAc)2 (8 mg, 0.33 mmol). The reaction mixture was stirred at 100° C. for 3 hrs, then quenched with water (20 mL) and extracted with EtOAc. The organic layer was washed with brine and dried over anhydrous Na2SO4. After purified by column chromatography (hexane/EtOAc=500:1), the target compound was obtained as brown yellow solid (50 mg, 17%). MS [M+]=366, LC-MS: tR=3.28 min.

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