HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 641814Generated: October 31, 2026
Potassium Carbonate → {2-[(2,3-Dimethoxy-quinoxalin-6-ylmethyl)-amino]-5-prop-2-ynyloxy-phenyl}-(4-isopropyl-phenyl)-methanone
https://huagongshe.com/reaction/641814
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 6-Bromomethyl-2,3-dimethoxy-quinoxaline | HCID 20545450 | — |
| Reactant | (2-Amino-5-(prop-2-yn-1-yloxy)phenyl)(4-isopropylphenyl)methanone | HCID 45139628 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | {2-[(2,3-Dimethoxy-quinoxalin-6-ylmethyl)-amino]-5-prop-2-ynyloxy-phenyl}-(4-isopropyl-phenyl)-methanone | HCID 11755527 | — |
Reaction Steps
To a solution of 82 mg (0.280 mmol) (2-amino-5-propargyloxy-phenyl)-(4-isopropyl-phenyl)-methanone in 3 ml dioxane is added 193 mg (1.40 mmol) potassium carbonate and 119 mg (0.419 mmol) 6-Bromomethyl-2,3-dimethoxy-quinoxalin. The mixture is stirred at 80° C. for two days, diluted with water and extracted with CH2Cl2. Purification of the crude product by chromatography (ethyl acetate/hexanes 1:1) affords a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07696216B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-57d53e03261446d4bcfde7573313cff9 |
|---|
| Source note | uspto-grants-2010_04 |
|---|
