Sodium Hydroxide → 5-Allyl-1-benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-1H-quinazolin-2-one

HRID 641850Notes

Reaction equation

HRID 641850 reaction equation
[CH2:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:5]=1[C:19]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=1)=O)[CH:2]=[CH2:3].[O-:30][C:31]#[N:32].[Na+].[OH-].[Na+]>C(O)(=O)C>[CH2:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]2[C:5]=1[C:19]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=1)=[N:32][C:31](=[O:30])[N:11]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 517096Sodium CyanateHCID 45141177(2-Allyl-6-benzylamino-3-hydroxy-phenyl)-(4-isopropyl-phenyl)-methanone

Product 1

HCID 451413895-Allyl-1-benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-1H-quinazolin-2-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 15 mg (39 μmol) (2-allyl-6-benzylamino-3-hydroxy-phenyl)-(4-isopropyl-phenyl)-methanone and 2.5 mg sodium cyanate in 0.2 ml acetic acid is stirred at r.t. for 16 h. Aqueous sodium hydroxide solution is added and the product is extracted with dichloromethane.

Workup

  1. extractionthe product is extracted with dichloromethane

Sources & evidence

ORD record
ord-3417843fbeca43efb9a8cb45fada7b44
Source dataset
uspto-grants-2010_04
Patent number
US07696216B2

Reaction notes

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