Sodium Cyanate → HCID 59259078, compound

HRID 641854Notes

Reaction equation

HRID 641854 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][NH:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]#[CH:24])=[CH:17][C:16]=2[C:25]([C:27]2[CH:32]=[CH:31][C:30]([CH:33]([CH3:35])[CH3:34])=[CH:29][CH:28]=2)=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[O-:36][C:37]#[N:38].[Na+].C(OCC)(=O)C.O>CC(O)=O>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][CH2:13][N:14]2[C:15]3[C:16](=[CH:17][C:18]([O:21][CH2:22][C:23]#[CH:24])=[CH:19][CH:20]=3)[C:25]([C:27]3[CH:32]=[CH:31][C:30]([CH:33]([CH3:35])[CH3:34])=[CH:29][CH:28]=3)=[N:38][C:37]2=[O:36])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

5

Reactant 3

HCID 517096Sodium CyanateHCID 22728543Water ethylacetateHCID 59259032HCID 59259032, compound

Product 1

HCID 59259078HCID 59259078, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 338 mg (0.72 mmol) of the product prepared in step C in 6 ml AcOH is treated with 70 mg (1.1 mmol) sodium cyanate. The mixture is stirred for 1.5 h at rt. A yellow product results after work-up with ethyl acetate/water, which is purified by chromatography (CH2Cl2/MeOH) to afford a yellow foam.

Workup

  1. customis purified by chromatography (CH2Cl2/MeOH)
  2. customto afford a yellow foam

Sources & evidence

ORD record
ord-0b27541526b94a5c98f86d7dc7424c55
Source dataset
uspto-grants-2010_04
Patent number
US07696216B2

Reaction notes

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