Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | HCID 59259078 | HCID 59259078 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 59259035 | HCID 59259035 | — |
Reaction Steps
A mixture of 130 mg (0.26 mmol) of the quinazolinone prepared in step D and 122 mg (0.30) mmol Lawesson reagent in 5 ml benzene is stirred for 2 h at 70° C. The solution turns slightly red. Equal amounts of Lawesson reagent are added after a total of 3 and 5 h, but the reaction remained incomplete. After extractive work-up with ethyl acetate and water, followed by chromatography of the crude material (hexane/ethyl acetate) the intermediate is obtained as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07696216B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-993a69e4dabc41dfbec8c6c1135307a3 |
|---|
| Source note | uspto-grants-2010_04 |
|---|
