HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Thiosulfate → 2-(3,4-Dimethoxyphenyl)-2-methylpropanal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Thiosulfate | HCID 24477 | — |
| Reactant | Triacetoxyperiodinane | HCID 159087 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-(3,4-Dimethoxyphenyl)-2-methylpropan-1-ol | HCID 13015778 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(3,4-Dimethoxyphenyl)-2-methylpropanal | HCID 59259113 | — |
Reaction Steps
A solution of 100 mg (0.476 mmol) 2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol in 1 ml dichloromethane is treated with 202 mg (0.476 mmol) Dess-Martin reagent at rt. After 1 h aqueous sodium bicarbonate and sodium thiosulphate solutions are added and the product is extracted with dichloromethane. The organic layers are evaporated and the aldehyde is obtained in a sufficient purity to be used in reductive aminations.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696216B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-dddd08e6850b4021b07f404df645263b |
| Source note | uspto-grants-2010_04 |