HCID 59259150, compound → HCID 59259074, compound

HRID 641858Notes

Reaction equation

HRID 641858 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][C:22]#[CH:23])=[CH:16][C:15]=2[C:24]([C:26]2[CH:31]=[CH:30][C:29]([CH:32]([CH3:34])[CH3:33])=[CH:28][CH:27]=2)=O)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[O:35]([C:37]#[N:38])[Na]>C(O)(=O)C>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([CH2:11][CH2:12][N:13]2[C:14]3[C:15](=[CH:16][C:17]([O:20][CH2:21][C:22]#[CH:23])=[CH:18][CH:19]=3)[C:24]([C:26]3[CH:27]=[CH:28][C:29]([CH:32]([CH3:33])[CH3:34])=[CH:30][CH:31]=3)=[N:38][C:37]2=[O:35])[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1

Participants

4

Reactant 2

HCID 59259150HCID 59259150, compoundHCID 178418852HCID 178418852, compound

Product 1

HCID 59259074HCID 59259074, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 15 mg (33 μmol) {2-[2-(3,5-dimethoxy-phenyl)-ethylamino]-5-prop-2-ynyloxy-phenyl}-(4-isopropyl-phenyl)-methanone and 2.1 mg (33 μmol) NaOCN in 300 μl acetic acid is stirred for 1 h at rt. The solvent is evaporated and the product is recrystallised from CH2Cl2/diethyl ether.

Workup

  1. customThe solvent is evaporated
  2. customthe product is recrystallised from CH2Cl2/diethyl ether

Sources & evidence

ORD record
ord-4b334b60ecbe45dbb2caff366c5cbfa0
Source dataset
uspto-grants-2010_04
Patent number
US07696216B2

Reaction notes

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