Potassium Hydroxide → HCID 68602613, compound

Participants

Reaction Conditions

Reaction Steps

KOH (3.96 g, 70.71 mmol) was added to a solution of 6-nitro-1H-indole (5 g, 30.86 mmol) in methanol (50 mL). 1-methylpiperidin-4-one (4.53 g, 40.09 mmol) was then added, and the resulting solution was stirred for 6 hours at 90° C. After cooling, the mixture was concentrated and the residue was recrystallized from ethanol (20 mL) to afford 3.0 g (36%) of 3-(1-methylpiperidin-4-yl)-6-nitro-1H-indole as a yellow powder.

Provenance & Evidence