Stannous Chloride → HCID 59259345, compound

HRID 641873Notes

Reaction equation

HRID 641873 reaction equation
[Sn](Cl)Cl.[CH3:4][N:5]1[CH2:10][CH:9]=[C:8]([C:11]2[C:19]3[C:14](=[CH:15][C:16]([N+:20]([O-])=O)=[CH:17][CH:18]=3)[N:13]([S:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)(=[O:25])=[O:24])[CH:12]=2)[CH2:7][CH2:6]1>CO>[CH3:4][N:5]1[CH2:6][CH:7]=[C:8]([C:11]2[C:19]3[C:14](=[CH:15][C:16]([NH2:20])=[CH:17][CH:18]=3)[N:13]([S:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)(=[O:24])=[O:25])[CH:12]=2)[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 24479Stannous ChlorideHCID 24743831HCID 24743831, compound

Product 1

HCID 59259345HCID 59259345, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Tin (II) chloride (2 g, 9.35 mmol) was added to a solution of 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-6-nitro-1-(phenylsulfonyl)-1H-indole (100 mg, 0.25 mmol) in methanol (30 mL). The resulting solution was stirred for 2 hours at reflux temperature After cooling to room temperature, the mixture was concentrated by evaporation to provide 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1-(phenylsulfonyl)-1H-indol-6-amine, which was used in the next stage without further purification.

Workup

  1. temperatureat reflux temperature
  2. concentrationthe mixture was concentrated by evaporation

Sources & evidence

ORD record
ord-221e7c46d1f34b768acecc3b65fdc9e6
Source dataset
uspto-grants-2010_04
Patent number
US07696229B2

Reaction notes

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