HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 641910Generated: October 25, 2026
Sulfuric Acid → 4-(Pyrrolidin-1-YL)benzenesulfonic acid
https://huagongshe.com/reaction/641910
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 1-Phenylpyrrolidine | HCID 77726 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-(Pyrrolidin-1-YL)benzenesulfonic acid | HCID 22147101 | 47.2% |
Reaction Steps
A solution of H2SO4 (6.8 g, 68.00 mmol) in diethylether (80 mL) was added to 1-phenylpyrrolidine (10 g, 68.03 mmol) in diethylether (20 mL) at 0° C. The diethylether was decanted, and the resulting solution was stirred for 3 hours at 170° C., then concentrated in vacuo to afford 7.3 g (43%) of 4-(pyrrolidin-1-yl)benzenesulfonic acid as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07696229B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-fcdcf67793a74eb0b5e9c1631abd2ed2 |
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| Source note | uspto-grants-2010_04 |
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