1-(2-Methoxyethyl)piperazine → methyl 4-methyl-3-[6-(4-(2-methoxyethyl)piperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzoate

Participants

Reaction Steps

Using an analogous procedure to that described paragraph (B) in the portion of Example 1 which is concerned with the preparation of starting material N-(2-methoxyethyl)piperazine was reacted with methyl 3-(6-bromo-4-oxoquinazolin-3(4H)-yl)-4-methylbenzoate to give methyl 4-methyl-3-[6-(4-(2-methoxyethyl)piperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzoate; NMR Spectrum: (DMSOd6) 2.18 (s, 3H), 2.55 (t, 2H), 2.60 (m, 4H), 3.25 (s, 3H), 3.27 (m, 4H), 3.50 (t, 2H), 3.88 (s, 3H), 7.47 (s, 1H), 7.62 (m, 3H), 7.97 (s, 1H), 8.01 (m, 1H), 8.09 (s, 1H); Mass Spectrum: M+H+ 437.

Provenance & Evidence