3-Isoxazolamine → 3-[6-[4-(cyclopropylmethyl)piperazin-1-yl]-4-oxoquinazolin-3(4H)-yl]-N-isoxazol-3-yl-4-methylbenzamide

Participants

Reaction Steps

Using an analogous procedure to that described paragraph (A) in the portion of Example 4, 3-[6-[4-(cyclopropylmethyl)piperazin-1-yl]-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoic acid was reacted with 3-aminoisoxazole to give 3-[6-[4-(cyclopropylmethyl)piperazin-1-yl]-4-oxoquinazolin-3(4H)-yl]-N-isoxazol-3-yl-4-methylbenzamide; NMR Spectrum: (DMSOd6) 0.02 (m, 2H), 0.37 (m, 2H), 0.77 (m, 1H), 2.08 (s, 3H), 2.13 (m, 2H), 2.51 (m, 4H), 3.19 (m, 4H), 6.95 (s, 1H), 7.38 (s, 1H), 7.52 (m, 3H), 7.96 (m, 2H), 8.03 (s, 1H), 8.76 (s, 1H), 11.36 (s, 1H); Mass Spectrum: M+H+ 485.

Provenance & Evidence