Sodium Hydroxide → 3-[6-[4-(cyclopropylmethyl)piperazin-1-yl]-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoic acid

Participants

Reaction Steps

Using an analogous procedure to that described paragraph (C) in the portion of Example 1 which is concerned with the preparation of starting material methyl 3-[6-[4-(cyclopropylmethyl)piperazin-1-yl]-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoate was hydrolysed with 1N NaOH to give 3-[6-[4-(cyclopropylmethyl)piperazin-1-yl]-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoic acid; NMR Spectrum: (DMSOd6) 0.42 (m, 2H), 0.68 (m, 2H), 1.15 (m, 1H), 2.16 (s, 3H), 3.07 (s, broad, 2H), 3.18 (s, 4H), 3.64 (s, broad, 2H), 4.02 (s, broad, 2H), 7.59 (m, 3H), 7.70 (m, 2H), 7.92 (s, 1H), 8.00 (d, 1H), 8.15 (s, 1H), 10.52 (s, broad, 1H), 13.06 (s, broad, 1H); Mass Spectrum: M+H+ 419.

Provenance & Evidence