3-Isoxazolamine → HCID 11997173, compound

HRID 641987Notes

Reaction equation

[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[N:11]1[C:20](=[O:21])[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([CH2:22][N:23]3[CH2:28][CH2:27][O:26][CH2:25][CH2:24]3)[CH:18]=2)[N:13]=[CH:12]1.[NH2:29][C:30]1[CH:34]=[CH:33][O:32][N:31]=1>>[O:32]1[CH:33]=[CH:34][C:30]([NH:29][C:6](=[O:8])[C:5]2[CH:9]=[CH:10][C:2]([CH3:1])=[C:3]([N:11]3[C:20](=[O:21])[C:19]4[C:14](=[CH:15][CH:16]=[C:17]([CH2:22][N:23]5[CH2:24][CH2:25][O:26][CH2:27][CH2:28]5)[CH:18]=4)[N:13]=[CH:12]3)[CH:4]=2)=[N:31]1

Participants

Reactant 2

HCID 18102163-Isoxazolamine

HCID 685167144-Methyl-3-[6-(4-morpholinylmethyl)-4-oxo-3(4H)-quinazolinyl]benzoic acid

Product 1

HCID 11997173HCID 11997173, compound

Procedure

Using an analogous procedure to that described paragraph (A) in the portion of Example 4, 4-methyl-3-[6-(morpholin-4-ylmethyl)-4-oxoquinazolin-3(4H)-yl]benzoic acid was reacted with 3-aminoisoxazole to give N-isoxazol-3-yl-4-methyl-3-[6-(morpholin-4-ylmethyl)-4-oxoquinazolin-3(4H)-yl]benzamide; NMR Spectrum: (DMSOd6) 2.21 (s, 3H), 2.41 (t, 4H), 3.60 (t, 4H), 3.65 (s, 2H), 7.06 (d, 1H), 7.62 (d, 1H), 7.77 (d, 1H), 7.87 (m, 1H), 8.10 (m, 2H), 8.15 (d, 1H), 8.32 (s, 1H), 8.86 (s, 1H), 11.47 (s, 1H); Mass Spectrum: M+H+ 446.

Sources & evidence

ORD record: ord-9fa49880b7984aa69b5227c6c3a53103
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696215B2

Reaction notes

Loading…