3-Isoxazolamine → HCID 11997171, compound

Participants

Reaction Steps

Using an analogous procedure to that described paragraph (A) in the portion of Example 4, 3-[6-{2-[dimethylamino]ethoxy}-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoic acid was reacted with 3-aminoisoxazole to give 3-[6-{2-[Dimethylamino]ethoxy}-4-oxoquinazolin-3(4H)-yl]-N-isoxazol-3-yl-4-methylbenzamide; NMR Spectrum: (DMSOd6) 2.17 (s, 3H), 2.25 (s, 6H), 2.70 (m, 2H), 4.19 (m, 2H), 7.04 (s, 1H), 7.50 (d, 1H), 7.60 (m, 2H), 7.72 (m, 1H), 8.07 (m, 2H), 8.20 (m, 1H), 8.83 (s, 1H), 11.45 (s, 1H); Mass Spectrum: M+H+ 434.

Provenance & Evidence