反应详情

温度

100 °C

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3dione in acetic acid was added 4-(trifluoromethoxy)benzohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 135 mg of the title compound (57%) as a yellow solid in 99.7% purity by HPLC (Rt: 6.39, gradient of 10 min, MaxPlot detection between 230 and 400 nm).

1. temperaturethe reaction mixture was cooled to rt
2. customa yellow solid precipitated out
3. filtrationFiltration on a fritté
4. washwashing with AcOH, water
5. customdrying under vacuo at 60° C. overnight