5-Iodoisatin → HCID 178497994, compound

Participants

Reaction Conditions

Reaction Steps

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added methyl 4-(hydrazinocarbonyl)benzoate. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 334 mg of the title compound (86%) as a yellow solid in 98.3% purity by HPLC (Rt: 5.21, gradient of 10 min, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence