5-Iodoisatin → methyl 4-[2-[2-(5-iodo-2-oxoindol-3-yl)hydrazinyl]-2-oxoethoxy]benzoate

関与物質

反応条件

反応手順

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added methyl 4-(2-hydrazino-2-oxoethoxy)benzoate. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 185 mg of the title compound (77%) as a yellow solid in 99.1% purity by HPLC (Rt: 5.34, gradient of 10 min, MaxPlot detection between 230 and 400 nm).

情報源と証拠