5-Iodoisatin → HCID 178509874, compound

Participants

Reaction Conditions

Reaction Steps

Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-cyano-N-[4-(hydrazinocarbonyl)phenyl]benzamide. After stirring at 100° C. the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 95 mg of the title compound (89%) as a orange powder in 94.7% purity by HPLC (Rt: 4.37, gradient of 8 min, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence