Acetic Acid → HCID 178517211, compound

Participants

Reaction Conditions

Reaction Steps

Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-[4-(1,3-oxazinan-3-ylmethyl)phenoxy]benzohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 194 mg of the title compound (67%) as a yellow solid in 98.9% purity by HPLC (Rt: 3.27, gradient of 8 min, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence