5-Iodoisatin → N'-(5-iodo-2-oxoindol-3-yl)-4-phenylmethoxybenzohydrazide

Participants

Reaction Conditions

Reaction Steps

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-(benzyloxy)benzohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 247 mg of the title compound (90%) as a yellow powder in 98.9% purity by HPLC (Rt: 5.03, gradient of 8 min, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence