反应详情

To a stirred solution of methyl 4-(aminomethyl)benzoate (75 g, 0.46 mol) and TEA (315 mL, 2.27 mol) in anhydrous DCM (1.5 L) was added a solution of freshly prepared 4-chloro benzoyl chloride (0.91 mol) in DCM (400 mL). The resulting mixture was allowed to stir for 12 hrs. The reaction was quenched with a 10% aqueous solution of sodium hydrogenocarbonate. The organic layer was washed with a 1.5N HCl solution and water. After drying over MgSO4 and evaporation of the solvent in vacuo, a solid was obtained. Recrystallization form MeOH gave the title compound (80 g) in a 60% yield as a white powder.

1. customThe reaction was quenched with a 10% aqueous solution of sodium hydrogenocarbonate
2. washThe organic layer was washed with a 1.5N HCl solution and water
3. dry with materialAfter drying over MgSO4 and evaporation of the solvent in vacuo
4. customa solid was obtained
5. customRecrystallization
6. customform MeOH