反应详情

温度

100 °C

Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added (±)-1-benzoyl-4-piperidinecarbohydrazide. After stirring at 100° C. the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 221 mg of the title compound (88%) as a yellow solid in 94.1% purity by HPLC (Rt: 3.93, gradient of 8 min, MaxPlot detection between 230 and 400 nm).

1. temperaturewas cooled to rt
2. customa yellow solid precipitated out
3. filtrationFiltration on a fritté
4. washwashing with AcOH, water
5. customdrying under vacuo at 60° C. overnight