5-Iodoisatin → HCID 178520465, compound

Participants

Reaction Conditions

Reaction Steps

Into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added N-[4-(hydrazinocarbonyl)phenyl]-3-(3-hydroxyphenyl)propanamide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 45 mg of the title compound (63%) as a yellow solid in 92.4% purity by HPLC (Rt: 3.88, gradient of 8 min, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence