反应详情

温度

100 °C

A suspension of 5-bromo-1H-indole-2,3-dione (67 mg, 0.30 mmol and) and 4-(3-hydrazino-3-oxopropyl)benzohydrazide (0.03 mg, 0.13 mmol) in acetic acid (2 mL) was heated at 100° C. for 80 min. The reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration, washing with AcOH (3×1 mL) and with AcOH/water (2×1 mL) and water (3×1 mL) and drying in vacuo at 70° C. for 4 hrs gave 68 mg of the title compound in a 79% yield as a yellow solid.

1. temperatureThe reaction mixture was cooled to rt
2. customa yellow solid precipitated out
3. filtrationFiltration
4. washwashing with AcOH (3×1 mL) and with AcOH/water (2×1 mL) and water (3×1 mL)
5. customdrying in vacuo at 70° C. for 4 hrs