5-Bromoisatin → HCID 178497968, compound

Participants

Reaction Conditions

Reaction Steps

Following the general method as outlined in Example 1, into a suspension of 5-bromo-1H-indole-2,3dione in acetic acid was added methyl 3-(2-hydrazino-2-oxoethoxy)benzoate. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 39 mg of the title compound (34%) as a orange powder in 97.5% purity by HPLC (Rt: 4.26, gradient of 8 min, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence