5-Bromoisatin → HCID 178521383, compound

Participants

Reaction Conditions

Reaction Steps

Following the general method as outlined in Example 1, into a suspension of 5-bromo-1H-indole-2,3-dione in acetic acid was added 2-[4-(1H-tetrazol-5-yl)phenoxy]acetohydrazide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 40 mg of the title compound (68%) as a orange Solid in 94.9% purity by HPLC (Rt: 3.34, gradient of 8 mini, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence