3-(Hydrazinosulphonyl)benzoic acid → HCID 178517221, compound

Participants

Reaction Conditions

Reaction Steps

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 3-(hydrazinosulfonyl)benzoic acid. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 131 mg of the title compound (71%) as a yellow solid in 87.8% purity by HPLC (Rt: 4.71, gradient of 10 min, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence