HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dodecylamine → HCID 68409673, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dodecylamine | HCID 13583 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | 2,3-dioxoindoline-7-carboxylic acid | HCID 2779383 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68409673 | HCID 68409673 | — |
Reaction Steps
Into a solution of 2,3-dioxo-7-indolinecarboxylic acid (1000 mg, 5.23 mmol), 1-dodecanamine (1066 mg, 5.75 mmol), TEA (1.60 mL, 11.51 mmol), EDCI.HCl (1102 mg, 5.75 mmol) and HOBt (777 mg, 5.75 mmol) in DMF (60 mL). The resulting mixture was allowed to stir at rt for 24 hrs. The solvent was evaporated off and the residue was taken up in DCM to be purified by flash chromatography using DCM/MeOH (98/2) as eluant. A gummy orange solid was collected to be identified as the title compound (44%) in a 96.0% purity by HPLC (MaxPlot detection between 230 and 400 nm).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696231B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-55b1df818aff4a09b0349652ca15c8c8 |
| Source note | uspto-grants-2010_04 |