5-Iodoisatin → HCID 178514758, compound

Participants

Reaction Conditions

Reaction Steps

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid was added 4-[(2-hydrazino-2-oxoethyl)thio]-3-nitrobenzenesulfonamide. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 60° C. overnight gave 24 mg of the title compound (61%) as a yellow solid in 99.3% purity by HPLC (Rt: 3.51, 4.17, gradient of 8 rnin, MaxPlot detection between 230 and 400 nm).

Provenance & Evidence