Acetic Acid → HCID 178500268, compound

Participants

Reaction Conditions

Reaction Steps

Following the general method as outlined in Example 1, into a suspension of 5-iodo-1H-indole-2,3-dione in acetic acid in the presence of 5% TFA was added tert-butyl 2-{4-[(9-methoxy-9-oxononanoyl)amino]benzoyl)hydrazinecarboxylate. After stirring at 100° C., the reaction mixture was cooled to rt and a yellow solid precipitated out. Filtration on a fritté, washing with AcOH, water and drying under vacuo at 70° C. for 21 hrs gave 611 mg of the title compound (95%) as a yellow solid in 98.1% purity by HPLC (MaxPlot detection between 230 and 400 nm).

Provenance & Evidence