Sodium Hydroxide → HCID 178525474, compound

Participants

Reaction Steps

Into a suspension of methyl 4-{3-[(4-{[3-(1,3-benzodioxol-5-yl)propanoyl]amino}benzoyl)hydrazono]-5-iodo-2-oxo-2,3-dihydro-1H-indol-1-yl}butanoate (150 mg, 0.22 mmol) in THF/H2O (2/1) (10 mL) was added NaOH (1.0 N, 1.1 mL). The resulting solution was stirred at rt for 2 hr and quenched with HCl (5 N, 4 mL). A yellow solid precipitated out. Filtration, washing with water (4×10 mL) and drying under vacuo at 60° C. for 15 hrs gave the title compound as a yellow powder (90 mg, 58%) in 95.5% purity by HPLC (MaxPlot detection between 230 and 400 nm).

Provenance & Evidence