2-(Bromomethyl)pyridine hydrobromide → 2,6-Difluoro-4-(pyridin-2-ylmethoxy)-benzoic Acid Methyl Ester

HRID 642177Notes

Reaction equation

HRID 642177 reaction equation
[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:9]([F:10])=[CH:8][C:7]([OH:11])=[CH:6][C:5]=1[F:12].Br.Br[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1>>[CH3:1][O:2][C:3](=[O:13])[C:4]1[C:5]([F:12])=[CH:6][C:7]([O:11][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)=[CH:8][C:9]=1[F:10]

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 22087431Methyl 2,6-difluoro-4-hydroxybenzoate

Product 1

HCID 576851242,6-Difluoro-4-(pyridin-2-ylmethoxy)-benzoic Acid Methyl Ester

Procedure

The title compound is prepared in a manner substantially analogous to Procedure E from 2,6-Difluoro-4-hydroxy-benzoic acid methyl ester and 2-(bromomethyl)pyridine hydrobromide. MS (ES+) 280

Sources & evidence

ORD record
ord-0ac095cd3c9544a683063b8750173a50
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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