HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(Chloromethyl)-2-(trifluoromethyl)pyridine → (2-(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-[4-(6-trifluoromethyl-pyridin-3-ylmethoxy)-phenyl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(Chloromethyl)-2-(trifluoromethyl)pyridine | HCID 2773810 | — |
| Reactant | (4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone | HCID 11960316 | — |
| Product | (2-(S)-Pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-[4-(6-trifluoromethyl-pyridin-3-ylmethoxy)-phenyl]-methanone | HCID 11711729 | — |
Reaction Steps
The title compound is prepared in a manner substantially analogous to Procedure C using (4-Hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 3-(chloromethyl)-6-(trifluoromethyl)pyridine. MS (ES+) 434.2
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696234B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-73ea064b5c584f4dae58acd77d2e1614 |
| Source note | uspto-grants-2010_04 |