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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 642195Generated: October 31, 2026

1-(Chloromethyl)-4-methanesulfonylbenzene → [2-Fluoro-4-(4-methanesulfonyl-benzyloxy)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

https://huagongshe.com/reaction/642195

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Chloromethyl)-4-methanesulfonylbenzeneHCID 123530—
Reactant(2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 59259534—
Product[2-Fluoro-4-(4-methanesulfonyl-benzyloxy)-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanoneHCID 11619545—

Reaction Steps

The title compound is prepared in a manner substantially analogous to Procedure C from (2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 4-methylsulfonylbenzyl chloride. MS (ES+) 461.2

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07696234B2
Source datasetuspto-grants-2010_04
ORD IDord-1b1cd8caf69f4f3a9b16f12157b4697b
Source noteuspto-grants-2010_04