2-Chloro-5-(chloromethyl)pyridine → [4-(6-Chloro-pyridin-3-ylmethoxy)-2-fluoro-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

HRID 642198Notes

Reaction equation

HRID 642198 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[CH:4][C:3]=1[C:9]([N:11]1[CH2:15][CH2:14][CH2:13][C@H:12]1[CH2:16][N:17]1[CH2:21][CH2:20][CH2:19][CH2:18]1)=[O:10].[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([CH2:29]Cl)=[CH:25][N:24]=1>>[Cl:22][C:23]1[N:24]=[CH:25][C:26]([CH2:29][O:8][C:6]2[CH:5]=[CH:4][C:3]([C:9]([N:11]3[CH2:15][CH2:14][CH2:13][C@H:12]3[CH2:16][N:17]3[CH2:21][CH2:20][CH2:19][CH2:18]3)=[O:10])=[C:2]([F:1])[CH:7]=2)=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 1554792-Chloro-5-(chloromethyl)pyridineHCID 59259534(2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Product 1

HCID 11546207[4-(6-Chloro-pyridin-3-ylmethoxy)-2-fluoro-phenyl]-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Procedure

The title compound is prepared in a manner substantially analogous to Procedure C using (2-Fluoro-4-hydroxy-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 2-chloro-5-(chloromethyl)pyridine [CAS 70258-18-3]. MS (ES+) 418.3

Sources & evidence

ORD record
ord-89cc6aab6297499cbf5990d7a2d5593f
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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