(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine → HCID 11675951, compound

HRID 642209Notes

Reaction equation

HRID 642209 reaction equation
CO[C:3](=[O:20])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[N:13]=2)=[CH:6][C:5]=1[F:19].[CH3:21][C@@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1[CH2:27][C@@H:28]1[CH2:32][CH2:31][CH2:30][NH:29]1>>[F:19][C:5]1[CH:6]=[C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH3:18])[N:13]=2)[CH:8]=[CH:9][C:4]=1[C:3]([N:29]1[CH2:30][CH2:31][CH2:32][C@H:28]1[CH2:27][N:23]1[CH2:24][CH2:25][CH2:26][C@H:22]1[CH3:21])=[O:20]

Participants

3

Reactant 2

HCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidineHCID 576851082-Fluoro-4-(6-methyl-pyridin-2-ylmethoxy)-benzoic Acid Methyl Ester

Product 1

HCID 11675951HCID 11675951, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure F from 2-Fluoro-4-(6-methyl-pyridin-2-ylmethoxy)-benzoic acid methyl ester and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) 412.3

Sources & evidence

ORD record
ord-f8a1e0a2d07c4616a1ef2333bf0af5bc
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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