4-Fluoroaniline → 1,5-Bis-(4-fluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

HRID 642225Notes

Reaction equation

HRID 642225 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[N:8]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:7]=1[CH3:24])=[O:5])[CH3:2].C(OC(=O)C(CC(C1C=CC([F:42])=CC=1)=O)C(=O)C)C.FC1C=CC(N)=CC=1>>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)[N:8]([C:18]2[CH:23]=[CH:22][C:21]([F:42])=[CH:20][CH:19]=2)[C:7]=1[CH3:24])=[O:5])[CH3:2]

Participants

4

Reactant 3

HCID 97314-FluoroanilineHCID 141739732-Acetyl-4-(4-fluorophenyl)-4-oxobutyric acid ethyl esterHCID 143391945-(4-Fluoro-phenyl)-2-methyl-1-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester

Product 1

HCID 143391951,5-Bis-(4-fluoro-phenyl)-2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

Procedure

Prepared in analogy to that of 5-(4-fluoro-phenyl)-2-methyl-1-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester from 2-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-oxo-butyric acid ethyl ester and 4-fluoroaniline. The title compound, ESI MS (m/z): 342 (M+H+).

Sources & evidence

ORD record
ord-5cfd82ff68314db28d3c940a5fa531ef
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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