HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloropinacolone → Ethyl 2-acetyl-5,5-dimethyl-4-oxohexanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloropinacolone | HCID 83572 | — |
| Reactant | 2-Acetyl-4-(4-fluorophenyl)-4-oxobutyric acid ethyl ester | HCID 14173973 | — |
| Product | Ethyl 2-acetyl-5,5-dimethyl-4-oxohexanoate | HCID 11775940 | — |
Reaction Steps
Prepared in analogy to that of 2-[2-(4-fluoro-phenyl)-2-oxo-ethyl]-3-oxo-butyric acid ethyl ester from 1-chloro-3,3-dimethyl-butan-2-one. The title compound, 1H NMR (200 MHz, CDCl3): δ (ppm)=4.19 (q, 2H, J=7.2 Hz), 4.02 (m, 1H), 3.23 (dd, 1H, J=8.2 Hz, 18.4 Hz), 3.00 (dd, J=6.0 Hz, J=18.4 Hz), 2.37 (s, 3H), 1.8 (t, 3H, J=7.2 Hz), 1.17 (s, 9H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07696223B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-45519a9c31844280b2c2d4d28e6c878e |
| Source note | uspto-grants-2010_04 |