3-bromo-2-tert-butyl-1-(4-fluoro-phenyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester → 2-tert-Butyl-1-(4-fluoro-phenyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

HRID 642243Notes

Reaction equation

HRID 642243 reaction equation
C(OC(C1C(O)=C2C=C(C3C=CC(F)=CC=3)N(C3C=CC=CC=3)C2=CN=1)=O)C.[CH2:29]([O:31][C:32]([C:34]1[C:35]([OH:55])=[C:36]2[C:42](Br)=[C:41]([C:44]([CH3:47])([CH3:46])[CH3:45])[N:40]([C:48]3[CH:53]=[CH:52][C:51]([F:54])=[CH:50][CH:49]=3)[C:37]2=[CH:38][N:39]=1)=[O:33])[CH3:30]>>[CH2:29]([O:31][C:32]([C:34]1[C:35]([OH:55])=[C:36]2[CH:42]=[C:41]([C:44]([CH3:47])([CH3:46])[CH3:45])[N:40]([C:48]3[CH:49]=[CH:50][C:51]([F:54])=[CH:52][CH:53]=3)[C:37]2=[CH:38][N:39]=1)=[O:33])[CH3:30]

Participants

3

Reactant 2

HCID 684263893-bromo-2-tert-butyl-1-(4-fluoro-phenyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl esterHCID 684278502-(4-Fluoro-phenyl)-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

Product 1

HCID 684266302-tert-Butyl-1-(4-fluoro-phenyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

Procedure

Prepared in analogy to that of 2-(4-fluoro-phenyl)-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester from 3-bromo-2-tert-butyl-1-(4-fluoro-phenyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester. The title compound, ESI MS (m/z): 357 (M+H+).

Sources & evidence

ORD record
ord-32222ddec05645cdb171e0e965529255
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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