Carbon Tetrachloride → 3,7-Dichloro-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

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Reaction Steps

A mixture of 4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (270 mg, 0.956 mmol), NCS (269 mg, 2.01 mmol) and BzOOBz (12 mg, 0.048 mmol) in carbontetrachloride (4 mL) was refluxed for 30 min. Then the reaction was cooled and concentrated, the resulting mixture was purified by column to give the desired product (173 mg). The title compound, 1H NMR (200 MHz, CDCl3): δ (ppm)=11.8 (s, 1H), 7.6-7.3 (m, 6H), 4.52 (q, 2H, J=6.8 Hz), 1.47 (t, 3H, J=6.8 Hz).

Provenance & Evidence