Ammonium formate → HCID 68428987, compound

Participants

Reaction Steps

To a mixture of 1-benzo[1,3]dioxol-5-ylmethyl-3-bromo-2-(4-chloro-phenyl)-4-hydroxy-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (200 mg, 0.38 mmol)(from Example 35(e)) in EtOAc (4 mL) was added palladium/char coal (Pd/C)(10% wet, containing 50% water) (95 mg) and ammonium formate (HCO2NH4)(495 mg, 7.86 mmol). The mixture was refluxed for 2 h. After cooled, it was diluted with EtOAc and then filtered through a pad of celite. Filtrate was concentrated and the residue was purified by silica gel chromatography (eluting with 30%-60% EtOAc/hexanes) to give the title compound 125 mg. MS-(+)-ion: M+1=417.13.

Provenance & Evidence