Tetramethyltin → HCID 68428537, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1-benzo[1,3]dioxol-5-ylmethyl-3-bromo-2-(4-chloro-phenyl)-4-(2,2-dimethyl-propionyloxy)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester (from Example 38(a))(180 mg, 0.29 mmol) in DMF (2.5 mL) was added tetramethyltin (207 mg, 1.16 mmol) and Pd(PPh3)2Cl2 (30 mg, 0.044 mmol). Resulting mixture was stirred at 130° C. for 2 h. Reaction mixture was diluted with EtOAc and filtered. Filtrate was washed with water and brine, dried over MgSO4, filtered, and concentrated to give the title product 161 mg. MS-(+)-ion: M+1=549.14.

Provenance & Evidence