反应详情

A mixture of 4-methyl-2-(4-phenoxy-phenyl)-thiazole-5-carboxylic acid ethyl ester (1.40 g, 4.14 mmole), N-bromosuccinimide (760 mg, 4.27 mole) and benzoyl peroxide (50 mg, 0.21 mmole) in carbon tetrachloride (18 ml) was refluxed for 8 h before it was cooled to room temperature and partitioned between dichloromethane and water. The organic layer was washed with saturated aqueous sodium bicarbonate solution, brine, dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a yellow oil (1.69 g). MS: (+) m/z 417.87, 419.87 (M+1, 79Br/81Br).

1. temperaturewas refluxed for 8 h before it
2. custompartitioned between dichloromethane and water
3. washThe organic layer was washed with saturated aqueous sodium bicarbonate solution, brine
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated in vacuo