Glycine → HCID 24757416, compound

Participants

Reaction Steps

A mixture of 4-cyano-2-(4-fluoro-phenyl)-7-hydroxy-thiazolo[4,5-c]pyridine-6-carboxylic acid ethyl ester (67 mg, 0.19 mmole) and glycine (875 mg, 11.66 mmole) in 0.5 M sodium methoxide/methanol (9.7 ml) was refluxed for 22 h before it was cooled to room temperature and concentrated in vacuo. The residue was dissolved in water (50 ml) and extracted twice with dichloromethane. The remaining aqueous layer was acidified to pH=3 with 1N HCl (12 ml). The suspension was extracted with ethyl acetate. The organic layer was washed with water and dried in vacuo to give the title compound as a yellow solid (59 mg). MS: (+) m/z 373.24 (M+1).

Provenance & Evidence