Glycine → HCID 24757417, compound

Participants

Reaction Steps

A mixture of 4-cyano-7-hydroxy-2-(3-methoxy-phenyl)-thiazolo[4,5-c]pyridine-6-carboxylic acid ethyl ester (34 mg, 0.10 mmole) and glycine (538 mg, 7.16 mmole) in 0.5 M sodium methoxide/methanol (9.5 ml) was refluxed for 21 h before it was cooled to room temperature and concentrated in vacuo. The residue was dissolved in water (25 ml) and extracted twice with dichloromethane. The remaining aqueous layer was acidified to pH=3 with 1N HCl (7 ml). The suspension was extracted with ethyl acetate and dichloromethane. The organic layers were combined and washed with water, dried over anhydrous sodium sulfate and concentrated in vacuo to give the title compound as a yellow solid (34 mg). MS: (+) m/z 385.17 (M+1), MS: (−) m/z 383.13 (M−1).

Provenance & Evidence